KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V47F was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V47F in KCNE1_HUMAN

Point mutation:	V47F
Domain:	TRANSMEM I
General numbering (KChannelDB):	149
Protein:	KCNE1_HUMAN (KCNE)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNE1_HUMAN
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 47 in IsK related channels (minK,MiRP,AMMECR2) family Position 47 in Potassium channels 1 TM family
Reference:	MinK subdomains that mediate modulation of and association with KvLQT1. Tapper AR, George AL Jr J Gen Physiol 2000 Sep;116(3):379-90.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

V47F

The two other MinK mutants , V47F and L51H , reside in the transmembrane domain
V47F MinK shifts the KvLQT1 voltage dependence of activation to more positive potentials compared with wild-type (Bianchi et al. 1999 (image) )

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005