KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V4C was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V4C in IRK2_BOVIN

Point mutation:	V4C
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	IRK2_BOVIN (KCNJ2,IRK)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK2_BOVIN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position
Reference:	Cyclic nucleotide-gated channels: intra- and extracellular accessibility to Cd2+ of substituted cysteine residues within the P-loop. Becchetti A, Roncaglia P Pflugers Arch 2000 Aug;440(4):556-65.	Medline
Other point mutations / same article	List
Text source	abstract
Validation status	Not yet checked

Relevant sentences:

V4C

The accessibility of V4C , S6C , T16C , 117C , T20C , P22C and S27C from the cytoplasmic side of the plasma membrane was tested by applying 1-100 microM Cd2+ to the inner face of inside-out patches , at negative membrane potentials
In contrast , V4C , T20C and P22C residues were only inhibited when 100 microM Cd2+ was applied externally , suggesting that V4C , T20C and P22C face the outer side of the P-loop.

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005