KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation S74L was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation S74L in KCNE1_MOUSE

Point mutation:	S74L
Domain:	C-term
General numbering (KChannelDB):	-
Protein:	KCNE1_MOUSE (Kcne)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in KCNE1_MOUSE
Family alignments	IsK related channels (minK,MiRP,AMMECR2) Potassium channels 1 TM
Other point mutations / same position	Position 74 in IsK related channels (minK,MiRP,AMMECR2) family Position 74 in Potassium channels 1 TM family
Reference:	The long QT syndromes: genetic basis and clinical implications. Chiang CE, Roden DM J Am Coll Cardiol 2000 Jul;36(1):1-12.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

S74L

Both mutations (S74L , D76N) reduced I Ks by shifting the voltage dependence of activation and accelerating channel deactivation
It has also been shown that mutant I Ks channels formed with D76N and S74L minK subunits have lower unitary currents and diminished open probabilities [79 ]

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005