KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation N126Q was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation N126Q in IRK3_HUMAN

Point mutation:	N126Q
Domain:	Loop 1-2
General numbering (KChannelDB):	-
Protein:	IRK3_HUMAN (KCNJ3,GIRK)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK3_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 107 in Inward rectifiers (Kir) family Position 107 in Potassium channels 2 TMs family
Reference:	Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, Thornhill WB J Biol Chem 2000 Sep 29;275(39):30677-82.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

N126Q

Might a non-canonical N-glycosylation site on the extracellular linker between M1 and M2 be responsible for some of the ~p70 band? The mutants GIRK1(N126Q) , GIRK1(N119Q / N126Q) , and G4(N132Q) / G1A were constructed , and their cRNAs were injected into oocytes for radiolabeling and immunoprecipitation

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005