KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation D79N was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation D79N in IRK6_HUMAN

Point mutation:	D79N
Domain:	N-term
General numbering (KChannelDB):	-
Protein:	IRK6_HUMAN (KCNJ6,GIRK2, KATP2, KCNJ)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in IRK6_HUMAN
Family alignments	Inward rectifiers (Kir) Potassium channels 2 TMs
Other point mutations / same position	Position 50 in Inward rectifiers (Kir) family Position 50 in Potassium channels 2 TMs family
Reference:	Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity. Kuzhikandathil EV, Oxford GS J Gen Physiol 2000 Jun;115(6):697-706.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

D79N

They found that a mutation of the { alpha}2A receptor (D79N) previously shown to block coupling of the receptor to GIRK channels , but not to calcium channels , could blunt agonist-induced inhibition of ACTH secretion when expressed in AtT20 cells , suggesting a role for GIRK channels in the action of these exogenous receptors

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005