KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation G628S was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation G628S in KCNH2_HUMAN

Point mutation:	G628S
Domain:	Loop 5-6
General numbering (KChannelDB):	-
Protein:	KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG)	Swiss-Prot Cross-reference table Family page
Protein isoforms	4
Other point mutations / same protein / same position	Point mutations at position 628 in KCNH2_HUMAN
Other point mutations / same protein	List of mutations in KCNH2_HUMAN
Family alignments	eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs
Other point mutations / same position	Position 628 in eag related KCNH (Kv10-12) family Position 616 in K+ voltage-gated channels (Kv1-12,Kca2-5) family Position 376 in Potassium channels 6 TMs family
Reference:	Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutant. Lees-Miller JP, Duan Y, Teng GQ, Thorstad K, Duff HJ Circ Res 2000 Mar 17;86(5):507-13.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

G628S

Further evidence for the formation of heteromultimers is provided by the observation that coexpression of the dominant-negative G628S HERG1 A (n = 3) with N629D resulted in dominant loss of expression (data not shown)

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005