KChannelDB: Extraction of mutation data from the literature

2005, KChannelDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation G628C was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation G628C in KCNH2_HUMAN

Point mutation:	G628C
Domain:	Loop 5-6
General numbering (KChannelDB):	-
Protein:	KCNH2_HUMAN (KCNH2,ERG, ERG1, HERG, HERG)	Swiss-Prot Cross-reference table Family page
Protein isoforms	4
Other point mutations / same protein / same position	Point mutations at position 628 in KCNH2_HUMAN
Other point mutations / same protein	List of mutations in KCNH2_HUMAN
Family alignments	eag related KCNH (Kv10-12) K+ voltage-gated channels (Kv1-12,Kca2-5) Potassium channels 6 TMs
Other point mutations / same position	Position 628 in eag related KCNH (Kv10-12) family Position 616 in K+ voltage-gated channels (Kv1-12,Kca2-5) family Position 376 in Potassium channels 6 TMs family
Reference:	Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. Mitcheson JS, Chen J, Sanguinetti MC J Gen Physiol 2000 Mar;115(3):229-40.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	Not yet checked

Relevant sentences:

G628C

However , when other mutations (G628C , S631C) that remove inactivation (Smith et al. 1996 (image) ) were introduced into the D540K HERG background , the rate of activation was easily discernible (Fig 1 C) , with time constants of 15 ą 1 and 92 ą 8 ms at 0 mV (n = 9)
(C) Inactivation-removed mutant HERG (D540K:G628C:S631C) currents activated by pulses ranging from -50 to +50 mV (top) and -100 to -160 mV (bottom)
Wang et al. 1997 (image) reported that block of wild-type HERG by E-4031 required 10-fold less compound than block of a mutant HERG (G628C:S631C) that removes inactivation

F.Horn (kchanneldbcmbi.ru.nl), 17-Aug-2005